Article: ADR - Different Results for Different Levels..

[Tim]

Hi all
Got this article from Medscape Orthopaedics and thought others might find it of interest..
The full article can be accessed at:
http://www.medscape.com/viewarticle/557712?src=mp
- you may have to register with medscape to view it.


Total Lumbar Disc Replacement: Different Results for Different Levels
Posted 06/14/2007

Christoph J. Siepe, MD; H Michael Mayer, MD, PhD; Matthias Dipl. Heinz-Leisenheimer, Psych.; Andreas Korge, MD

Abstract

Study Design: Prospective study analyzing midterm clinical results of total lumbar disc replacement (TDR) with ProDisc II performed at different lumbar motion segments.
Objectives: To assess the influence of the disc level and number of discs replaced following TDR on postoperative outcome.
Summary of Background Data: Multisegmental disc replacement procedures belong to the so-called off- label indications for disc replacement, which still lack evidence of noninferiority when compared with fusion procedures. Results from uncontrolled clinical trials regarding monosegmental versus multisegmental disc replacements are contradictory.
Methods: The influence of the level and the number of lumbar discs replaced on postoperative outcome was analyzed prospectively according to Visual Analogue Scale (VAS), Oswestry Disability Index (ODI), and numerous clinical parameters. Post-TDR pain patterns were analyzed with fluoroscopically guided spine infiltrations.
Results: A total of 99 patients from 3 treatment groups with a mean follow-up of 25.8 months (range, 12.1-57.5 months) achieved significant improvement of preoperative VAS and ODI levels (P < 0.05). Best results and highest patient satisfaction rates (90.9%) were achieved in patients with monosegmental TDR at L4-L5 (n = 22). Results deteriorated when monosegmental TDR was performed at the lumbosacral junction (n = 57) with a tendency toward statistical significance at 24-month follow-up (P = 0.07). Postoperative outcome was significantly inferior following bisegmental disc replacements at L4-L5 + L5-S1 (n = 20) with a considerably higher complication rate when compared with monosegmental TDR procedures. Fluoroscopically guided spine infiltrations confirmed that the incidence of postoperative pain from posterior joint structures was 9.1% (n = 2) for L4-L5 TDR, 28.1% (n = 16) following L5-S1, and 60.0% (n = 12) for bisegmental-TDR at L4-L5 + L5-S1, respectively.
Conclusion: The level and the number of lumbar disc replacements influence postoperative outcome significantly. Satisfactory outcome was achieved for monosegmental L4-L5 and L5-S1 disc replacement procedures with best results achieved following TDR at L4-L5. For bisegmental TDR, complication rates are significantly higher and inferior postoperative results are to be expected. The incidence of postoperative pain originating from facet and/or iliosacral joints is currently underestimated and will require further investigation.

All the best
Tim

[mmglobal]

Tim, thanks for the article. I'm not sure what to make of this. Although some of the authors have been ADR heavy-hitters, this group recently published a study with horribly inferior results with ProDisc-C. Thier results were so much worse than the norm, the take-home message about ProDisc-C was .... "Don't go to those guys for PD-C" It'll be interesting to see what else they publish.

I got your PM... yes, I've been running too hard. In the last 2 months I've had a trip to NY and 3 trips to Europe (5 weeks). I'm ablout ready to fall over. I'll be back in the office on Tuesday... contact me late next week.

[Maria]

This is an interesting article, looking forward to more in depth studies with greater numbers involved~ by that time I may well be a statistic too... so far I just fall into the "failed back" stats..

Mark,
Your perspective is one that I find particularly important to hear since you're in the midst of what's happening globally and you've nothing to gain other than more knowledge and ability to serve the spinal community in an unbiased way~